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The terrific carnitine concentration gradient between epidydimal lumen and plasma is allowed by the presence of OCTN2 at the blood side and by the presence of another carnitine specific transporter, namely CT2 (SLC22A16) on the lumen side of epithelia (Gong et al., 2002)

doi: 10.1073/pnas.1213343109

Loss or damage to the ICCs appears to be a dominant abnormality [3, 6, 11], where altered immune function with a shift from M2 to M1 macrophage expression and impaired regulation of haem oxygenase 1 leading to increased oxidative stress may be responsible [6, 11]

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